Differentiation of DOTP and DNOP in analysis of restricted

  • Differentiation of DOTP and DNOP in analysis of restricted
  • Differentiation of DOTP and DNOP in analysis of restricted
  • Differentiation of DOTP and DNOP in analysis of restricted
  • Is MINP a metabolite of DINP?
  • However,MINP is only a minor urinary metabolite of DINP. Oxidative metabolites, including mono (carboxyisooctyl) phthalate (MCIOP), mono (oxoisononyl) phthalate (MOINP), and mono (hydroxyisononyl) phthalate (MHINP) are the major urinary metabolites in DINP-dosed rats.
  • Is monoisononyl phthalate a metabolite of DINP?
  • Traditionally, assessment of human exposure to DINP has been done using monoisononyl phthalate (MINP), the hydrolytic metabolite of DINP, as a biomarker. However,MINP is only a minor urinary metabolite of DINP.
  • How to differentiate DIBP and DBP using different fragmentation pattern?
  • Differentiation of DIBP and DBP using the different fragmentation pattern in MRM3 mode in comparison to MRM mode the LC method if throughput requires. Another possibility to enhance selectivity of detection is the use of Differential Mobility Spectrometry (DMS).
  • Does DOTP cause testicular lesions in Sprague-Dawley rats?
  • DOTP, which is isomeric with DEHP but reportedly not metabolized to MEHP, was inactive in the current study and failed to cause testicular lesions in young adult Sprague-Dawley rats (administered as 1% in the diet for 90 days, with treatment initiated at 8 weeks of age; Barber and Topping, 1995).
  • Does Maternal treatment with DINP increase the incidence of reproductive malformations?
  • Maternal treatment with DINP (0.75 g/kg/day from GD 14 to day 3 of lactation) significantly increased the incidence of male offspring with reproductive malformations on an individual (4/52, as shown here). One of the six permanent nipples seen in one male from the DINP group is shown here.
  • Which phthalate esters alter sexual differentiation of male rat and rabbit?
  • 1. Structure of phthalate esters which did (upper panel) or did not (middle panel) alter sexual differentiation of the male rat. Structure of dibutyl phthalate (DBP), which also alter sexual differentiation of the rat and rabbit, and the presumptive active metabolites of DBP (MBP) and DEHP (MEHP). FIG. 2.

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