Pharmaceutically Used Plasticizers-IntechOpen Kenya

  • Pharmaceutically Used Plasticizers-IntechOpen Kenya
  • Pharmaceutically Used Plasticizers-IntechOpen Kenya
  • Pharmaceutically Used Plasticizers-IntechOpen Kenya
  • Are plasticizers suitable for pharmaceutical applications?
  • The extensive use of polymers in medical and pharmaceutical applications including particularly packaging, medical devices, drug carriers and coatings has caused a substantial demand for the proper plasticizers. Although there are many plasticizers used in the chemical industry, only a few of them have been approved for pharmaceutical applications.
  • Are natural-based plasticizers suitable for pharmaceutical and medical applications?
  • The natural-based plasticizers characterized by low toxicity and low migration are required nowadays not only for pharmaceutical and medical applications. In this respect, most of traditional plasticizers are not applicable in this area.
  • Is hydrophilic polymer an internal plasticizer of polymeric drug delivery systems?
  • As well structural water in the hydrophilic polymer seems to be an internal plasticizer of the polymeric drug delivery systems. In case of contact with body fluids after application the hydrophilic plasticizer can be released from polymer and thus conditions for the incorporated drug release are changed.
  • Are plasticizers a low molecular weight non-volatile additive?
  • Pharmaceutically used plasticizers The primary role of all plasticizers as low molecular weight non-volatile additives is to improve the flexibility and processability of polymers by lowering the second order transition temperature (glass transition temperature, Tg) (Rosen, 1993).
  • Why are water-insoluble plasticizers used in polymer dispersions?
  • ecially when water-insoluble plasticizers are used. Water insoluble plasticizers have to be emulsif ed in the aqueous phase of the polymer dispersions. During plasticization of the polymer dispersions, the plasticizer partitions into the colloidal polymer particles and softens them thus promoting particle
  • Are polymeric drug delivery systems plasticizers?
  • Plasticizer as minor component of polymeric drug delivery systems has not been strictly defined. Even liquid drugs or liquids with a potential pharmacodynamic effect can serve as plasticizers. As well structural water in the hydrophilic polymer seems to be an internal plasticizer of the polymeric drug delivery systems.

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