Substance Name: Dibutyl phthalate (DBP) CAS Number: 84-74-2 India

  • Substance Name: Dibutyl phthalate (DBP) CAS Number: 84-74-2 India
  • Substance Name: Dibutyl phthalate (DBP) CAS Number: 84-74-2 India
  • Substance Name: Dibutyl phthalate (DBP) CAS Number: 84-74-2 India
  • What is dibutyl phthalate (DBP)?
  • • Dibutyl phthalate (DBP) should be identified as a substance of equivalent level of concern to those of other substances listed in points (a) to (e) of Article 57 of Regulation (EC) No 1907/2006 (REACH) according to Article 57(f) of REACH Regulation.
  • Is dibutyl phthalate toxic?
  • According to Annex I to Directive 67/548/EEC, Dibutyl phthalate (DBP) is classified as a substance toxic to reproduction Repr. Cat. 2; R61 (May cause harm to the unborn child). Not relevant. Estrogenic activity of DBP has been shown in some special in vitro assays, however the effects were weak and not confirmed in in vivo studies.
  • Is dibutyl phthalate a CMR?
  • The substance is identified as a CMR according to Article 57 (c) of Regulation (EC) 1907/2006 (REACH). According to Annex I to Directive 67/548/EEC, Dibutyl phthalate (DBP) is classified as a substance toxic to reproduction Repr. Cat. 2; R61 (May cause harm to the unborn child). Not relevant.
  • What is dibutyl phthalate used for?
  • Dibutyl Phthalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and dietary supplements by chromatography. These Secondary Standards are qualified as Certified Reference Materials.
  • Is mono-butyl-phthalate a metabolite of DBP?
  • Fenell et al. (2004) investigated pharmacokinetics of DBP in pregnant rats and found Mono-butyl-phthalate to be the major metabolite of DBP. With increasing dose, there was a nonlinear increase in area under curve (AUC) for MBP, with a ten-fold increase in fetal plasma between 50 mg/kg and 250 mg/kg.
  • How does dibutylphthalate affect cytochrome p450a1?
  • Dibutylphthalate provoked liver peroxisome proliferation and up6regulation of cytochrome P450A1 in early life stages at the end of the exposure and in adult females. Dibutylphthalate also upregulated the expression of aromatase genes.

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